Application of Petri net to modularization analysis of metabolic networks

doi:10.3778/j.issn.1002-8331.2010.33.062

Computer Engineering and Applications ›› 2010, Vol. 46 ›› Issue (33): 218-220.DOI: 10.3778/j.issn.1002-8331.2010.33.062

• 工程与应用 • Previous Articles Next Articles

Application of Petri net to modularization analysis of metabolic networks

DING De-wu¹，HUANG Hai-sheng¹，WU Pu¹，WANG Ru-chuan²

Received:2010-02-24 Revised:2010-06-17 Online:2010-11-21 Published:2010-11-21
Contact: DING De-wu

Petri网在代谢网络模块化分析中的应用

丁德武¹，黄海生¹，吴璞¹，王汝传²

通讯作者: 丁德武

Abstract

Abstract: Modularization analysis of metabolic networks can be helpful to understand the structure and function of these networks.However，almost all current methods consider metabolic networks as general complex networks，and resulted modules are often of biological insignificance.By applying Petri net to riboflavin metabolism network in Bacillus subtilis，the results suggest that T-invariant of Petri net is usable for identifying functional modules in metabolic networks，with better biological significance.

Key words: Petri net, metabolic network, complex network, modularization

摘要： 代谢网络的模块化分析有助于理解网络的结构和功能。然而，当前众多的模块化分析方法大多将代谢网络考虑为普通的复杂网络，所得模块的生物学意义较低。对枯草芽孢杆菌的核黄素代谢进行Petri网建模分析，研究结果表明：Petri网的T不变量可用于识别代谢网络中的功能模块，具备较好的生物学意义。

关键词: Petri网, 代谢网络, 复杂网络, 模块化

CLC Number:

TP391

DING De-wu¹，HUANG Hai-sheng¹，WU Pu¹，WANG Ru-chuan². Application of Petri net to modularization analysis of metabolic networks[J]. Computer Engineering and Applications, 2010, 46(33): 218-220.

丁德武¹，黄海生¹，吴璞¹，王汝传². Petri网在代谢网络模块化分析中的应用[J]. 计算机工程与应用, 2010, 46(33): 218-220.

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Application of Petri net to modularization analysis of metabolic networks

Petri网在代谢网络模块化分析中的应用

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