Simulation of cellular signal transduction network based on Agent and FSM

doi:：10.3778/j.issn.1002-8331.2011.03.065

Computer Engineering and Applications ›› 2011, Vol. 47 ›› Issue (3): 221-224.DOI: ：10.3778/j.issn.1002-8331.2011.03.065

• 工程与应用 • Previous Articles Next Articles

Simulation of cellular signal transduction network based on Agent and FSM

YANG Tao¹，DENG Hongli²，SHAO Chenxi³

1.Laboratory Center of China West Normal University，Nanchong，Sichuan 637002，China
2.School of Computer Science and Technology，Southwest University of Science and Technology，Mianyang，Sichuan 621010，China
3.Department of Computer Science and Technology，University of Science and Technology of China，Hefei 230027，China

Received:2009-05-07 Revised:2009-06-28 Online:2011-01-21 Published:2011-01-21
Contact: YANG Tao

基于Agent和FSM的细胞信号转导网络仿真

杨韬¹，邓红莉²，邵晨曦³

1.西华师范大学实验中心，四川南充 637002
2.西南科技大学计算机科学与技术学院，四川绵阳 621010
3.中国科学技术大学计算机科学技术系，合肥 230027

通讯作者: 杨韬

Abstract

Abstract: Motivating from the shortcomings of existed methods for cellular signal transduction network simulation，a novel method based on Agent and Finite State Machine（FSM） is proposed.With the construction of the multi-agent system between the macro level and micro level，complex cellular signal transduction network is simulated.The intelligent Agent technology and FSM model for modeling molecules is syncretized，to simulate the molecular mechanisms of signal transduction effectively，and to reduce the external communication.Besides，qualitative simulation is used to simulate molecular conformations，reducing combinatorial complexity.Finally，the results obtained from the simulation demonstrate the effectiveness of the approach.

Key words: cellular signal transduction, complex network, modeling and simulation, Agent, Finite State Machine（FSM）

摘要： 针对现有细胞信号转导网络仿真方法的不足，提出一种基于Agent和FSM的仿真方法，在宏观水平与微观水平之间构建多Agent系统，仿真复杂的细胞信号转导网络。融合了智能Agent技术和FSM模型实现分子建模，有效地模拟了信号传递的分子机制，并减少了外部通信。采用定性仿真建模分子构象，降低了组合复杂性。通过仿真实验证明了方法的有效性。

关键词: 细胞信号转导, 复杂网路, 建模与仿真, Agent技术, 有限状态机

CLC Number:

TP391.9

YANG Tao¹，DENG Hongli²，SHAO Chenxi³. Simulation of cellular signal transduction network based on Agent and FSM[J]. Computer Engineering and Applications, 2011, 47(3): 221-224.

杨韬¹，邓红莉²，邵晨曦³. 基于Agent和FSM的细胞信号转导网络仿真[J]. 计算机工程与应用, 2011, 47(3): 221-224.

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Simulation of cellular signal transduction network based on Agent and FSM

基于Agent和FSM的细胞信号转导网络仿真

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