Computer Engineering and Applications ›› 2017, Vol. 53 ›› Issue (1): 23-28.DOI: 10.3778/j.issn.1002-8331.1605-0377

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Improvement based on regularization for building hybrid criteria model of radiotherapy planning

GUO Caiping1,2,3, SHU Huazhong4, GUI Zhiguo1, 2, ZHANG Pengcheng1,2   

  1. 1.National Key Laboratory for Electronic Measurement Technology, North University of China, Taiyuan 030051, China
    2.Key Laboratory of Instrument Science & Dynamic Measurement Technology,North University of China, Taiyuan 030051, China
    3.Department of Electronic Engineering, Taiyuan Institute of Technology, Taiyuan 030008, China
    4.Laboratory of Image Science and Technology, Southeast University, Nanjing 210096, China
  • Online:2017-01-01 Published:2017-01-10



  1. 1.中北大学 电子测试技术国家重点实验室,太原 030051
    2.中北大学 仪器科学与动态测试教育部重点实验室,太原 030051
    3.太原工业学院 电子工程系,太原 030008
    4.东南大学 影像科学与技术实验室,南京 210096

Abstract: To solve the problem existing in the physical-biological hybrid criteria model based on the generalized equivalent uniform dose linear objective function in conformal intensity-modulated radiation therapy, this paper presents a smooth and convex regularization of max function using regularization theory, and improves the hybrid criteria model based on the generalized equivalent uniform dose. When this improved model is applied in inverse planning optimization process, problems(searching ability of optimization algorithm is restricted and it is hard time predicting how large a step can be made when using a gradient-based optimization algorithm) existing in original model are circumvented. Compared to the original model, experiments show that the method using newly proposed model can get better protection to organs at risk while ensuring similar dose coverage for target and the quality of radiotherapy planning is improved.

Key words: intensity-modulated radiation therapy, generalized equivalent uniform dose, hybrid criteria, regularization

摘要: 针对调强放射治疗中基于等效均匀剂量线性目标函数的物理生物混合准则模型的不足,利用正则化理论构造了最大函数的平滑和凸正则化函数,改进了基于等效均匀剂量线性目标函数的混合准则放疗规划模型,解决了原模型限制优化算法寻优能力和难以确定梯度算法步长的问题。实验证明,该方法可以在保证相似靶区剂量覆盖特性的前提下,更好地保护危及器官,提高了放疗计划质量。

关键词: 调强放疗, 等效均匀剂量, 混合准则, 正则化