计算机工程与应用 ›› 2007, Vol. 43 ›› Issue (28): 61-64.

• 学术探讨 • 上一篇    下一篇

一种鉴定蛋白质突变和翻译后修饰的算法

谢靖宇,谢深泉   

  1. 湘潭大学 信息工程学院,湖南 湘潭 411105
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-10-01 发布日期:2007-10-01
  • 通讯作者: 谢靖宇

Algorithm identifying mutations and post-translational modification of protein

XIE Jing-yu,XIE Shen-quan   

  1. College of Information Engeering,Xiangtan University,Xiangtan,Hunan 411105,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-10-01 Published:2007-10-01
  • Contact: XIE Jing-yu

摘要: 提出的MSA(Modified Spectral Alignment)算法,改进了SA(Spectral Alignment)算法中D(k)和k-最佳Spectral Alignment的求解方式,并在算法中引入“双端考虑”。实验结果数据表明,MSA算法有效地提高了鉴定含突变或翻译后修饰的蛋白质的能力。

关键词: 蛋白质, 翻译后修饰, 突变, MSA算法

Abstract: The algorithm MSA is presented in this paper,which improved the way to compute D(k) and k-optimal Spectral Alignment of SA algorithm and took into account simultaneous analysis of N-terminal and C-terminal ions.The experiment result data shows that efficiently improves the capability of identifying proteins containing mutations or post-translational modifications.

Key words: protein, Post-translational Modification, mutation, MSA algorithm