关键词: 蛋白质相互作用, 蛋白质功能模块, 检测, 聚类

Abstract: Detection of protein functional modules in Protein-Protein Interaction（PPI） networks is helpful to predict the functional modules of unknown proteins. With the rapid growth of effective data of protein interaction, how to obtain effective protein functional modules through PPI network has become the biggest challenge. This paper describes the development and current situation of PPI network research, then summarizes the current detection algorithms of protein functional modules, divides them into unit clustering and multivariate clustering, and elaborates the representative methods of each category in detail. Finally, it discusses the challenges and the future research directions  of the PPI network functional module detection research.

Key words: protein-protein interaction, protein function module, detecting, clustering