关键词: 间歇生物过程, 动态优化, 最优操作, 甘油

Abstract: Dynamic optimization of batch bio-dissimilation process of glycerol is addressed. According to a nonlinear dynamic system on the batch bio-dissimilation process of glycerol, three dynamic optimization models are first proposed in terms of the fixed or free final time. These dynamic optimization models can maximize the concentration of 1, 3-propanediol and the production rate of 1, 3-propanediol at final time, respectively. Then an orthogonal collocation on finite elements method is applied to solve the proposed dynamic optimization problems. Finally, some analysis and discussions on the obtained optimization results for the three dynamic optimization problems are given. Compared with the existing result, a higher rate of 1, 3-propanediol production is obtained.

Key words: batch bioprocess, dynamic optimization, optimal operation, glycerol