Study on release models of chitosan gastric retenting-floating microspheres in vitro

doi:10.3778/j.issn.1002-8331.2009.33.067

Computer Engineering and Applications ›› 2009, Vol. 45 ›› Issue (33): 213-215.DOI: 10.3778/j.issn.1002-8331.2009.33.067

• 工程与应用 • Previous Articles Next Articles

Study on release models of chitosan gastric retenting-floating microspheres in vitro

HU Zhi-wen¹，ZHANG Jian²

1.College of Computer Science & Engineering，Wenzhou University，Wenzhou，Zhejiang 325035，China
2.Department of Applied Physics，Hefei University of Technology，Hefei 230009，China

Received:2008-06-30 Revised:2008-08-19 Online:2009-11-21 Published:2009-11-21
Contact: HU Zhi-wen

壳聚糖胃滞留-漂浮微球体外释药模型研究

胡智文¹，张鉴²

1.温州大学计算机科学与工程学院，浙江温州 325035
2.合肥工业大学应用物理系，合肥 230009

通讯作者: 胡智文

Abstract

Abstract: To demonstrate the release property of Chitosan Gastric Retenting-floating Microspheres（CGRM），the GM（1，1） model，Zero Order Dynamic Model（ZODM），Higuchi models and Ritger-Peppas（RPeppas） model are established.By analyzing the descriptive ability and predictive ability of the models，the results enunciate that all of them can perfectly simulate the release property.Both of the simulation accuracy and the prediction accuracy are summarized in an order of good to poor as GM（1，1），Higuchi，ZODM，RPeppas，and the GM（1，1） model is the best.

Key words: dynamic model, grey system theory, gastric retenting-floating microspheres, sustained-release, chitosan

摘要： 通过建立壳聚糖胃滞留-漂浮微球（CGRM）缓释性能的GM（1，1）模型、零级释放动力学模型（ZODM）、Higuchi模型和Ritger-Peppas（RPeppas）模型，并对各模型的模拟和预测性能进行了研究。结果表明四个模型均能较好地模拟和预测CGRM的缓释性能，模拟精度与预测精度优劣顺序相同，依次为：GM（1，1）>Higuchi>ZODM>RPeppas，其中GM（1，1）模型最优。

关键词: 动力学模型, 灰色系统理论, 胃滞留-漂浮微球, 缓释, 壳聚糖

CLC Number:

TP311

HU Zhi-wen¹，ZHANG Jian². Study on release models of chitosan gastric retenting-floating microspheres in vitro[J]. Computer Engineering and Applications, 2009, 45(33): 213-215.

胡智文¹，张鉴². 壳聚糖胃滞留-漂浮微球体外释药模型研究[J]. 计算机工程与应用, 2009, 45(33): 213-215.

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Study on release models of chitosan gastric retenting-floating microspheres in vitro

壳聚糖胃滞留-漂浮微球体外释药模型研究

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