Improved parameter optimization method and its applications in pharmacokinetics

doi:10.3778/j.issn.1002-8331.2010.26.064

Computer Engineering and Applications ›› 2010, Vol. 46 ›› Issue (26): 206-208.DOI: 10.3778/j.issn.1002-8331.2010.26.064

• 工程与应用 • Previous Articles Next Articles

Improved parameter optimization method and its applications in pharmacokinetics

LI Dan-xia¹，LIU Li¹，LAI Choi-Hong²

1.School of Information Technology，Jiangnan University，Wuxi，Jiangsu 214122，China
2.School of Computing and Mathematical Sciences，Greenwich Campus，London SE10 9LS，UK

Received:2009-01-12 Revised:2009-03-27 Online:2010-09-11 Published:2010-09-11
Contact: LI Dan-xia

一种改进的药代动力学参数优化方法及其应用

李丹侠¹，刘丽¹，厉才康²

1.江南大学信息工程学院，江苏无锡 214122
2.格林威治大学计算机与数学科学学院，英国伦敦 SE10 9LS

通讯作者: 李丹侠

Abstract

Abstract: An iterative partition-based concurrent simplex algorithm based on the PKAIN method for parameter optimization in pharmacokinetics is presented.Moreover，line network suppression is improved to simplify parameter setting.In addition，in order to improve search speed and performance，a hybrid algorithm with the advantages of artificial immune network and simplex method is presented.The artificial immune network is used to do coarse-grained search.Subsequently，the simplex method is applied to do search based on the results of the artificial immune network.A comparison of PKAIN_in method，hybrid algorithm PKAIN-spx，and PKAIN method is given.Experiments demonstrate that the PKAIN_spx has good performance for parameter optimization in pharmacokinetics.

Key words: artificial immune network, pharmacokinetics, simplex, parameter optimization

摘要： 基于药代动力学参数优化方法PKAIN人工免疫网络算法，提出了迭代分组并发单纯形算子，并实现了线性网络抑制函数以简化人工免疫网络的参数设置。为了加快算法的搜索速度和搜索精度，提出了新型的人工免疫网络单纯形混合算法（PKAIN_spx），用人工免疫网络实现粗粒度全局搜索，随后用单纯形进行精确搜索。仿真实验对改进的PKAIN算法（PKAIN_in）、人工免疫网络单纯形混合算法（PKAIN_spx）以及PKAIN算法进行了比较分析，结果表明PKAIN_spx算法在药代动力学参数优化中取得良好的实验效果。

关键词: 人工免疫网络, 药代动力学, 单纯形, 参数优化

CLC Number:

TP273

LI Dan-xia¹，LIU Li¹，LAI Choi-Hong². Improved parameter optimization method and its applications in pharmacokinetics[J]. Computer Engineering and Applications, 2010, 46(26): 206-208.

李丹侠¹，刘丽¹，厉才康². 一种改进的药代动力学参数优化方法及其应用[J]. 计算机工程与应用, 2010, 46(26): 206-208.

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Improved parameter optimization method and its applications in pharmacokinetics

一种改进的药代动力学参数优化方法及其应用

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