关键词: Ca²⁺浓度, 三维图像处理, 距离变换, 心肌细胞

Abstract: The spatio-temporal distribution of Ca2+ concentrations in a cardiac myocyte is helpful to get the parameters for circuit modeling of cardiac mycoyte rhythmic motion.A new method for studying the distribution of Ca2+ concentrations in cardiac myocytes was proposed.The sequence images of a cardiac myocyte sampled by Laser Scanning Confocal Microscopy（LSCM） were processed,3-D reconstructed,segmented,and distance transformed to divide the myocardial cell into shells from the membrane toward inside,and the spatio-temporal distribution of the Ca2+ concentration in the cardiac myocyte was got.3-D medical image processing is convenient to biology research and medical diagnosis,and 3-D distance transform method can also be applied to the analogous biomedical researches.

Key words: Ca²⁺ concentration, 3-D image processing, distance transform, cardiac myocyte