关键词: 血容量量化, 对比剂渗漏, 血液循环, 磁共振灌注成像

Abstract: Methods for improving the accuracy in cerebra blood volume（CBV） quantification using perfusion-weighted magnetic resonance imaging（PWI） are proposed with respect to contrast agent extravasation and blood recirculation，respectively.Contrast agent extravasation contaminated concentration curve are modeled as a linear combination of the normal concentration curve and its integration using a two-compartment model.Linear least squares algorithm is used to optimize the weights for correcting the over-estimation of CBV due to contrast agent extravasation.The first pass components of the corrected concentration curve are extracted via a deconvolution-convolution model and used to quantify CBV.Experimental results on simulations and PWIs from patients with Glioblastoma Multiform（GBM） prove the effectiveness of the proposed methods.

Key words: CBV quantification, contrast agent extravasation, blood recirculation, perfusion-weighted Magnetic Resonance Imaging