预测蛋白质结构拟物算法的研究与改进

doi:10.3778/j.issn.1002-8331.2010.26.065

计算机工程与应用 ›› 2010, Vol. 46 ›› Issue (26): 209-211.DOI: 10.3778/j.issn.1002-8331.2010.26.065

预测蛋白质结构拟物算法的研究与改进

李明，苏显中，于敏

中国矿业大学化工学院生物工程系，江苏徐州 221116

收稿日期:2009-01-06 修回日期:2009-03-23 出版日期:2010-09-11 发布日期:2010-09-11
通讯作者: 李明

Study and improvement on quasi-physical algorithm for protein structure prediction

LI Ming，SU Xian-zhong，YU Min

Department of Biological Engineering，School of Chemical Engineering，China University of Mining and Technology，Xuzhou，Jiangsu 221116，China

Received:2009-01-06 Revised:2009-03-23 Online:2010-09-11 Published:2010-09-11
Contact: LI Ming

摘要/Abstract

摘要： 研究了具有两种氨基酸（疏水氨基酸和亲水氨基酸）的三维非格点的蛋白质模型。给出了该模型蛋白质结构预测问题改进的拟物算法。氨基酸链的初始设置由完全随机改为随机线形结构，并找到了更优的计算参数。结果对于三个氨基酸链都找到了更好的最低势能值。

关键词: 蛋白质结构预测, 拟物算法, 三维非格点模型

Abstract: A three-dimensional off-lattice protein model，which has two species of different amino acids（aa），hydrophobic and hydrophilic is studied.An improved quasi-physical algorithm is formulated.The incipient set of the aa chain is changed into random line structure，and better parameters are found.For three of these instances，the algorithm finds new lowest energy configurations different from those in references.

Key words: protein structure prediction, quasi-physical algorithm, 3D off-lattice model

中图分类号:

Q518.2
TP301

李明，苏显中，于敏. 预测蛋白质结构拟物算法的研究与改进[J]. 计算机工程与应用, 2010, 46(26): 209-211.

LI Ming，SU Xian-zhong，YU Min . Study and improvement on quasi-physical algorithm for protein structure prediction[J]. Computer Engineering and Applications, 2010, 46(26): 209-211.

预测蛋白质结构拟物算法的研究与改进

Study and improvement on quasi-physical algorithm for protein structure prediction

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