关键词: 图像配准, 自由形变模型, 薄板样条, B样条, Bhattacharyya距离

Abstract: According to the feature that different organ has different deformation character，this paper presents a register algorithm based on local region constraints.The segmented bony structures in the two respective images are registered based on their boundary points，and then dense deformations in the entire images are interpolated by a thin plate spline interpolation technique.Bhattacharyya distance based B-Spline registration algorithm is used to iteratively refine the registration of soft tissues with different constraints，and at the same time keep the rigid transformation for each bony structure.The proposed registration algorithm has been applied to the clinical data with very encouraging results by two clinical radiologists.

Key words: image registration, free-form deformation, thin plate spline, B-Spline, Bhattacharyya distance