Abstract: Directed at the dissatisfaction status quo in the identification of Essential Protein（EP），two ways are put forward to improve the performance：one is to find out new parameters closer to EP，the other is to integrate some of known parameters.For its important role in the topology of networks，the Minimal Vertex Cover（MVC） is introduced into the study of EP in a protein network first time：the use of the algorithms relation to parameterized computing reduces the complexity of MVC problem of a protein network to a great extent so as to analyze the problem quickly and get a new topological parameter-Vertex Cover Parameter（VCP），with its closer relation to the essentiality of a protein.In-depth study，the degree of the relativity between known parameters，including VCP，is found out，which indicates the extent of the mutual complement of information of EP their containing.The integration of the information of the parameters is explored with this observation，and the identification ability is enhanced obviously in the simulation as results.