关键词: 频域光学相干断层（SD-OCT）, 糖尿病视网膜病变（DR）, 硬性渗出, 自适应阈值, 三维区域生长

Abstract: Hard exudation is one of symptoms in Diabetic Retinopathy（DR）. The bright speckles in Spectral Domain Optical Coherence Tomography（SD-OCT） have close relationship with exudation. In order to locate the lesion information in DR images, this paper proposes a method for extracting the bright speckles. The analysis includes four steps：denoise images with bilateral filtering, limit target regions by layer segmentation algorithm, grow regions using more large thresholds between the global threshold and single threshold by self-adaption threshold algorithm, grow again in the range of the seed images generated by other thresholds. 20 eyes with DR are selected to test, and the bright speckles coverage rate is increased by about 7% compared with the existing algorithm.

Key words: Spectral Domain Optical Coherence Tomography（SD-OCT）, Diabetic Retinopathy（DR）, hard exudation, self-adaption threshold, 3D region growing