关键词: Petri网, 代谢网络, 系统生物学

Abstract: The development of simulation and analysis methods for genome-scale metabolic network model can helpful for studying the structure and function’s relationship of these networks, and thus it is an important research topic in the field of computational system biology. With the rigorous mathematical formulation, the intuitive graphical expression, plus the many algorithms and tools, Petri nets may become a powerful tool for metabolic network modeling and analysis. In this paper, the place/transition Petri nets are used to analyze the structural and functional characteristics of the metabolic network. A Petri nets model of the metabolism of Pichia pastoris is established, and the P, T invariant in the Petri nets model is calculated, their significance is also discussed.

Key words: Petri nets, metabolic network, systems biology