关键词: 序列特征, 基因剪接, 剪接位点, 剪接调控元件

Abstract: There are various splicing signals involved in the gene alternative splicing regulatory process, for example splice sites and splicing regulatory elements and so on. How to identify these splicing signals and explore the signals distribution rules throughout the genome is an interesting question. This paper presents a scoring algorithm based on sequential features and this method gives each signal a special score indicating its strength. The classifier constructed based on this scoring algorithm can be used to identify new splicing signals. Beside, the study on the splice sites and splicing regulatory elements distribution throughout genome using scoring system uncovers the two types of signals with complementary characteristics. This paper shows a new method for biology series’ data analysis and presents a new way for the study of regulatory sequences that control gene expression.

Key words: sequential feature, gene splicing, splice sites, splicing regulatory elements