Abstract: Compartmental models have been successfully used to model biomedical and pharmacokinetical systems.The purpose of this paper is to present a positive robust control law for the feedback stabilisation of mass control for a class of positive compartmental systems which is under the presence of uncertainties，the proposed control law is Lyapunov-based and the closed-loop system is global asymptotic stable.The performance of mass control is illustrated for the case of neuromuscular blockade control of patients undergoing surgery，compared with other control law by simulations.