Abstract: Manufacturing information system with full integration needs the Statistical Process Control（SPC） method with diversification and agility to implement the product quality management decision based on practical data.A reconfigurable SPC system driven by common statistical analyzing software is proposed and implemented through analyzing and building a domain model of SPC.The system introduces powerful statistical analysis functions of common statistical analyzing software to implement visual statistical analysis.The component architecture and hot spots technology used by reconfigurable SPC system can meet the requirements of application mode reconstruction and configuration model reconstruction for SPC.At last，the reconfigurable SPC system is implemented based on SPSS（Statistical Package for the Social Science） software，with referencing SPSS components and executing SPSS Syntax commands.And an instance is shown to confirm that the system with well usability provide a digital method and application for total quality management of manufacturing enterprises.