Abstract: Lossless compression is usually used in the transmission of medical images in order to ensure the quality of images.That’s due to a digital medical image needs a large volume of storage and requires high-precision.However，such images will occupy considerable bandwidth，but also reduce the transmission speed.In this paper，a method with which multi-scale compression is applied to the region of interest and the region of non-interest of medical images is presented，and gain good result.Meanwhile，the results of this experiment are compared with other methods and it indicates that the method can effectively improve compression rate，thus increasing the transmission rate.