Abstract: In allusion to blind super-resolution images for recovery，an approach of blind super-resolution image reconstruct based on genetic algorithm is proposed.This approach builds a regularization energy function，where regularization is carried out in both the image and blur domains，minimizes the regularization by using global optimizing capacity of genetic algorithm，then gets the high resolution image from multiple frames degraded low resolution images，and also estimates the blurs.The results of simulation show that the approach is feasible.