关键词: 生物过程, 优化, 多目标, 最优操作, Pareto最优解

Abstract: Multi-objective optimization of continuous bio-dissimilation process of glycerol to 1, 3-propanediol is studied. According to a nonlinear dynamic system of enzyme-catalytic kinetics on the continuous bio-dissimilation process of glycerol to 1, 3-propanediol, four objectives are first proposed to maximize the production rate of 1, 3-propanediol, the conversion rate of glycerol bioconversion to 1, 3-propanediol, the conversion rate of glycerol and minimize the concentration of 3-hydroxypropionaldehyde. Then six new multi-objective nonlinear optimization models are established. These multi-objective problems can simultaneously optimize any two of the four objectives above to perform the continuous bio-dissimilation process of glycerol to 1, 3-propanediol. The Normal Boundary Intersection（NBI） method is used to solve the proposed multi-objective optimization problems. A filter strategy is adopted to eliminate the non-global Pareto points generated by the NBI method. Finally, some discussions on the obtained Pareto optimal solution sets and the Pareto fronts for the six multi-objective optimization problems are presented. This kind of analysis can provide a guide for achieving the optimal operation of continuous bio-dissimilation process of glycerol to 1, 3-propanediol.

Key words: bioprocess, optimization, multi-objective, optimal operation, Pareto optimal solution