Abstract: In this paper，a new approach of multi-modality image registration is represented with not only image intensity，but also features describing image structure.Two aspects of the registration are addressed to make this method feasible.Firstly，instead of standard MI（Mutual Information） based on joint intensity histogram，RMI（Regional Mutual Information） is employed，which allows neighborhood information to be taken into account.Secondly，the feature images obtained by means of phase congruency are invariants to brightness or contrast changes.By incorporating these feature images and original image into RMI，aspects of both structural and neighborhood information are combined together，which offers a more robust and a high level registration accuracy.