Abstract: Secure storage has become the concern of researchers in the information security domain in succession to secure communications.A hardware encryption scheme for USB mobile hard disk drive based on FPGA is designed and implemented，which adopts smart cards with built-in functions for security computation to carry out authentication as well as key acquisition and proposes a data integrity verification method working at the cluster level.Experimental results show significant improvement in system security and data access speed.The design can be applied to prevent information leakage caused by losing，stolen and disuse cases and illegal data modification of mobile hard disk drives.