Abstract: The performance of traditional adaptive noise cancellation algorithms is greatly suffered by cross-talk signals in two microphone speech enhancement applications.To promote the performance of two-microphone noise cancellation algorithms，a two-stage adaptive filter system is adopted to extract desired speech signal from the cross-talk signals.To accelerate the convergence，the master-slave adaptive filter algorithm is employed.To use narrow-band algorithm，the cross-talk-resist processing is adopted over each subbands of the input signals.The enhanced speech signal is the combination of all subbands signal.Experiment results show that this method is quite effective in speech enhancement as it can cancel a large amount of noise with little distortion to speech signals.